Pro API For Remote Operations - Taking 2 Minutes to Create User

Hoping someone can help out here. We have been a long time user and have extensively developed on S2. We have multiple membership site with well over 20k user each. We use the API set extensively and the last couple of days the Create user Api has ground to a halt, it takes roughly 2 minutes to add a user and has stopped giving a success response.

We have plenty of Server, Ram, Memory and database is separate from the web server so no bottle necks there

We have New Relic Full reporting connected to show errors at every level, code, database and server but no luck.

If we run get_user API it return the data in under a second in a database with 60k members

Any help or direction would be greatly appreciated.